This study examined the effects of adding the probiotic Saccharomyces cerevisiae to feed on feed efficiency, growth performance, digestive enzyme activity, and body biochemical composition of striped catfish (Pangasianodon hypophthalmus). The test fish were striped catfish with an initial average weight of 20.36±0.22 g fish-1. The test feed was a formulated pellet diet with S. cerevisiae probiotics added at different doses: T1, T2, T3, T4, and T5 (0, 1, 2, 3, and 4 g kg-1 feed, respectively). The test feed was administered using the ad satiation method thrice daily for 56 days. The results showed that adding S. cerevisiae probiotics to the feed significantly increased the feed efficiency, growth performance, digestive enzyme activity, and biochemical composition of striped catfish. Both feed efficiency and growth performance variables in striped catfish increased with increasing doses of S. cerevisiae probiotics. The same trend was observed for the digestive enzyme activity and biochemical composition of striped catfish. An additional 4 g kg-1 feed of probiotic S. cerevisiae was identified as the best dose for improving the productivity of striped catfish (P. hypophthalmus).
